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Human Medicine

Low Dose Naltrexone (LDN)

LDN refers to daily dosages approximately 10% of the typical opioid addiction treatment dose. At these low levels, naltrexone exhibits paradoxical properties — including analgesia and anti-inflammatory actions — shown to benefit patients with immune system dysfunction.

Immediate releaseDosing flexibilityFewer ingredients
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LDN Research Trust 2026 MemberTrusted Compounding Pharmacy

Low Dose Naltrexone that puts patients first.

Low Dose Naltrexone (LDN) refers to daily dosages of naltrexone that are approximately 10% or less of the typical opioid addiction treatment dosage, commonly up to 5mg. These dosages are compounded at compounding pharmacies and require a prescription. At the low dosage level, naltrexone exhibits paradoxical properties, including analgesia and anti-inflammatory actions, which have not been reported at larger dosages. Studies have shown that it can be beneficial for people with conditions marked by immune system dysfunction.

LDN represents the use of an established prescription medication in many other domains of medical treatment. Although many studies have shown promise with LDN therapy, more studies are being conducted to investigate the effectiveness of LDN in treating a range of autoimmune illnesses. LDN is frequently used in conjunction with the traditional prescription medications typical for treating these various conditions with the exception of narcotics.

Immediate releaseDosing flexibilityFewer ingredients

The LDN Pharmacy You Can Trust

Why doctors choose CareFirst Specialty Pharmacy

  • Nationally Accredited Compounding Pharmacy (PCAB/ACHC, .Pharmacy, PCCA and IACP Member.)
  • Tablets with dosing flexibility and fewer ingredients than capsules.
  • Immediate release tablets with no calcium, gluten, lactose, corn, dairy, soy or dyes.
  • Fillers that do not interfere with absorption.
  • State-of-the-art compounding facility with stringent quality control and independent lab testing.
  • Multiple strengths ready to ship from an experienced team with excellent service.
  • Licensed in over 50 states.

We Compound LDN

  • Tablets (0.5mg - 6mg)
  • Sublingual Tablets
  • Oral Sublingual Drops
  • Oral Suspensions (90-day beyond use date)
  • Veggie Capsules (Sucrose, Mannitol, Acidophilus, Loxoral, Vitamin C or other)
  • Topical Creams
  • Ultra Low Dose Naltrexone (ULDN)

This Medication Requires a Prescription

To process your order we will require a prescription from you or your prescriber. We will only compound and dispense upon receipt of a valid patient specific prescription.

Need help?

Our team can coordinate with your provider to get what you need quickly.

LDN Research Trust 2026 Member

LDN Research Trust 2026 Member badge

Accredited & recognized

CareFirst Specialty Pharmacy is proud to be an LDN Research Trust 2026 member.

Low Dose Naltrexone (LDN) Side Effects

LDN is known to be safe and well-tolerated with a minimal side effect profile. Common reports include vivid dreams and interrupted sleep during the initial adjustment; these tend to develop quickly and decrease over time.

LDN is compatible with most prescription medications except for narcotics. Because it blocks the effects of narcotics and could cause withdrawal symptoms, it should only be started after those drugs are out of your system.

Caution is taken with Hashimoto's patients as LDN can rapidly decrease autoimmune antibodies and may require a decrease in thyroid replacement medication as the body works more effectively.

Conditions LDN Has Been Prescribed For

  • ALS (Lou Gehrig's disease)
  • Alzheimer's disease
  • Ankylosing spondylitis
  • Anti-aging
  • Autism
  • Celiac disease
  • Chronic fatigue syndrome
  • Crohn's disease
  • Endometriosis
  • Fibromyalgia
  • Thyroid Disorders (Hashimoto's and Graves' Disease)
  • Inflammatory bowel disease
  • Lupus
  • Multiple sclerosis (MS)
  • Parkinson's disease
  • Psoriasis
  • Rheumatoid arthritis
  • Sarcoidosis
  • Scleroderma
  • Ulcerative colitis

Low Dose Naltrexone (LDN) Cost and Availability

LDN needs to be compounded by an experienced and accredited compounding pharmacy. It must be compounded as an immediate release capsule or tablet and without the use of certain fillers and binders. Pricing can vary considerably by region and pharmacy. Check our shipping information page to see what states we're licensed in!

LDN Informational Video

Hear more about how LDN is compounded, who it can benefit, and how our team supports you through prescription and refills.

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Available Low Dose Naltrexone Products

Explore strengths, fillers, and dosage forms tailored to your prescription.

HumanLow Dose Naltrexone
Low Dose Naltrexone

Low Dose Naltrexone

Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses. Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. Naltrexone at low doses (0.5mg - 6mg) has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses.

From$34.99
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HumanLow Dose Naltrexone
Naltrexone (Low Dose) Capsules Compounded

Naltrexone (Low Dose) Capsules Compounded

Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses. Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. Naltrexone at low doses (0.5mg - 6mg) has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses.

From$66.95
View Details
HumanLow Dose Naltrexone
Naltrexone (Low Dose) Sublingual Tablets Compounded

Naltrexone (Low Dose) Sublingual Tablets Compounded

Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses. Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. Naltrexone at low doses (0.5mg - 6mg) has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses.

From$42.92
View Details
HumanLow Dose Naltrexone
Naltrexone (Low Dose) Suspension Compounded

Naltrexone (Low Dose) Suspension Compounded

Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses. Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. Naltrexone at low doses (0.5mg - 6mg) has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses.

From$39.99
View Details
HumanLow Dose Naltrexone
Naltrexone (Low Dose) Topical Cream Compounded

Naltrexone (Low Dose) Topical Cream Compounded

Low dose naltrexone may be beneficial for the treatment of various conditions including chronic pain and autoimmune illnesses. Naltrexone is typically used to treat opioid use disorder and alcohol abuse disorder. It is classified as an opioid antagonist blocking the effects of exogenously administered opioids. Naltrexone at low doses (0.5mg - 6mg) has been prescribed for its possible analgesia and anti-inflammatory effects, which have not been observed at higher doses.

From$51.95
View Details

LDN Articles & Resources

Learn more about Low Dose Naltrexone from our pharmacy team.

LDN Patient Information

2019-11-11

LDN Patient Information

The LDN Research Trust is a UK registered Charity, founded in 2004, with the primary purpose of promoting research into the unlicensed use of Naltrexone at a low dose, to treat conditions and diseases. Naltrexone at a low dose is referred to as LDN (Low-Dose Naltrexone).

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LDN Prescriber Information

2019-11-04

LDN Prescriber Information

Naltrexone is often classified as an opiate antagonist. However, at low-doses, Naltrexone acts to inhibit certain inflammatory pathways, which involve Toll-Like Receptors (TLRs). Naltrexone’s traditional use is in treating addiction to opiate drugs, such as heroin or morphine, or to treat acute overdose of these opioids. The daily dose of Naltrexone used for this purpose is usually between 50 mg (moderate dose naltrexone) to 300mg (high dose Naltrexone). Similar levels of Naltrexone are using for acute dosing.

Read More
Low Dose Naltrexone (LDN) Basics: How It Works and Who It Helps

2024-05-10

Low Dose Naltrexone (LDN) Basics: How It Works and Who It Helps

Explore how Low Dose Naltrexone (LDN) is compounded, why prescribers choose it, and what patients should know before starting therapy.

Read More
Low Dose Naltrexone (LDN) for Fibromyalgia

2018-07-16

Low Dose Naltrexone (LDN) for Fibromyalgia

When you hear the word naltrexone your first instinct is most likely to think of this medication as something that is used to treat opioid or alcohol dependence. However, what if I were to tell you that patients suffering with fibromyalgia could use this medication to find relief and treat their pain? As strange as this may sound, breakthroughs in research in the recent years have actually shown that low dose naltrexone may potentially have a multitude of uses, including treating autoimmune diseases, pain and central nervous system disorders. This article will explore why low dose naltrexone (LDN) may be not be such a far-fetched idea for treating fibromyalgia.

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Low-Dose Naltrexone in Sjogren’s Syndrome

2021-08-12

Low-Dose Naltrexone in Sjogren’s Syndrome

The current data for the use of LDN for Sjogren’s Syndrome is limited to case reports only. These case reports, though, are encouraging for LDN’s potential utility in the disease. There are three case reports that detail LDN use in SS, in which all patients are female and have diagnosed SS with symptoms of dry eyes and mouth, joint pain, fatigue, and general pain.

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Low Dose Naltrexone Therapy for Crohn’s Disease

2018-07-17

Low Dose Naltrexone Therapy for Crohn’s Disease

Crohn’s Disease is a debilitating form of chronic inflammatory bowel disease (IBD). It is estimated that 3 million people in the US alone have a form of IBD. There is currently no cure for Crohn’s which is usually characterized by frequent diarrhea, abdominal pain, unexplained weight loss, fatigue, and anemia. Normal therapies include immunosuppressive drugs including steroids, but 80% of patients will need surgical intervention within 20 years of diagnosis. There is evidence that low dose naltrexone can achieve symptom relief in some patients who have moderate symptoms despite normal therapies.

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