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Methylene Blue
Methylene blue is an oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. You may buy Methylene Blue from CareFirst Specialty Pharmacy with a valid prescription from your prescriber.
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Price: as low as $44.95
Please Note: Due to market volatility, prices are subject to change. Please contact us for the most current pricing.
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This medication requires a prescription.
To process your order we will require a prescription from you or your Prescriber. We will only compound and dispense upon receipt of a valid patient specific prescription.
- Your prescriber can mail or fax in the prescription
- You can mail in the original prescription
- We can contact your prescriber for you
- You can transfer your prescription from another pharmacy
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Fax Your Prescription
Fax (800) 786-1405 or (844) 922-7379 and we’ll process it right away.
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Call our pharmacists at (844) 822-7379 with prescription details.
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Complete the prescriber form and we’ll follow up quickly.
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csr@cfspharmacy.com for questions, refills, or status updates.
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Pharmacy Info
We are a nationally accredited PCAB compounding pharmacy and a .Pharmacy verified website. A verified .Pharmacy website designation ensures our patients and prescribing partners that our website is verified and safe.
https://safe.pharmacy/buy-safely/?url=cfspharmacy.pharmacy
Drug Description
Actual product image may vary.
Product Info
Clinical content written by Julia Ossman, 2027 PharmD Candidate, Philadelphia College of Pharmacy
Methylene Blue
Methylene blue, also called methylthioninium chloride, has historically been used as a diagnostic dye and as a treatment for methemoglobinemia, but it has potential for off-label use in many other clinical situations. Dosing may be prescribed based on its intended use, which can vary from patient to patient. Here at CareFirst Specialty Pharmacy, we can compound methylene blue into capsules of various strengths.
Pronunciation: METH-uh-leen bloo
Active Ingredient & How It Works
Methylene Blue — Drug class: antidote, diagnostic agent. Also available commercially under the brand name ProvayBlue. Methylene blue promotes a reduction-oxidation conversion of methemoglobin to hemoglobin, restoring hemoglobin’s ability to efficiently carry oxygen in the blood. It can also carry electrons to cytochrome C, bypassing parts of the mitochondrial electron transport chain that are not functioning properly, and produces vasoconstrictive effects by inhibiting nitric oxide synthase and guanylate cyclase.
Possible Side Effects
Common side effects may include dizziness, nausea, headache, diarrhea, teeth staining, and discoloration of urine or skin.
Tell your doctor immediately if you experience any of the following while taking methylene blue:
🚨 Allergic reaction: Trouble breathing, swelling of the face, rash, hives, or itching.
🚨 Serotonin syndrome: Agitation, hallucinations, delirium, fast heart rate, dizziness, seizures, nausea, vomiting, or diarrhea.
🚨 Hemolytic anemia: Weakness, pale or yellowish skin, or dizziness.
Drug Interactions
Avoid concomitant use with serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), and opioids. Taking serotonergic drugs together with methylene blue increases the risk of serotonin syndrome.
Warning: Do not take this medication if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency, due to an increased risk of hemolytic anemia.
Administration & Dosing
Use this medication exactly as prescribed. Contact your healthcare provider for specific dosing instructions.
Pregnancy, Breastfeeding & Pediatrics
Methylene blue may have the potential to cause fetal harm. Consult your healthcare provider if you are pregnant to discuss the risks and benefits. It is unknown whether methylene blue is excreted in human breast milk; one manufacturer recommends discontinuing breastfeeding during treatment and for up to 8 days after administration due to an increased risk of adverse reactions. Methylene blue may be safe and effective in neonates, infants, children, and adolescents — consult your healthcare provider for more information.
⚠️ Disclaimer: This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.
References
- DailyMed. PROVAYBLUE (methylene blue) injection [Internet]. Bethesda (MD): U.S. National Library of Medicine; 2025 May 28 [cited 2026 Jun 22]. Available from: dailymed.nlm.nih.gov
- Drugs.com. Methylene blue: uses, dosage, side effects, warnings [Internet]. Drugsite Trust; 2025 May 5 [cited 2026 Jun 22]. Available from: drugs.com
- Tatarinova O, Lund K, Bain BJ. Beware of methylene blue in possible G6PD deficiency. Am J Hematol. 2024;99(10):2016-2017. doi:10.1002/ajh.27324.
Active Ingredients
Methylene Blue
Directions
Consult your prescriber.
Instructions
Use the medication as prescribed by your doctor. The information provided is not intended to cover all possible uses. This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.
Shipping
Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.
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We are a nationally accredited PCAB compounding pharmacy and a .Pharmacy verified website. A verified .Pharmacy website designation ensures our patients and prescribing partners that our website is verified and safe.
https://safe.pharmacy/buy-safely/?url=cfspharmacy.pharmacy
Actual product image may vary.
Clinical content written by Julia Ossman, 2027 PharmD Candidate, Philadelphia College of Pharmacy
Methylene Blue
Methylene blue, also called methylthioninium chloride, has historically been used as a diagnostic dye and as a treatment for methemoglobinemia, but it has potential for off-label use in many other clinical situations. Dosing may be prescribed based on its intended use, which can vary from patient to patient. Here at CareFirst Specialty Pharmacy, we can compound methylene blue into capsules of various strengths.
Pronunciation: METH-uh-leen bloo
Active Ingredient & How It Works
Methylene Blue — Drug class: antidote, diagnostic agent. Also available commercially under the brand name ProvayBlue. Methylene blue promotes a reduction-oxidation conversion of methemoglobin to hemoglobin, restoring hemoglobin’s ability to efficiently carry oxygen in the blood. It can also carry electrons to cytochrome C, bypassing parts of the mitochondrial electron transport chain that are not functioning properly, and produces vasoconstrictive effects by inhibiting nitric oxide synthase and guanylate cyclase.
Possible Side Effects
Common side effects may include dizziness, nausea, headache, diarrhea, teeth staining, and discoloration of urine or skin.
Tell your doctor immediately if you experience any of the following while taking methylene blue:
🚨 Allergic reaction: Trouble breathing, swelling of the face, rash, hives, or itching.
🚨 Serotonin syndrome: Agitation, hallucinations, delirium, fast heart rate, dizziness, seizures, nausea, vomiting, or diarrhea.
🚨 Hemolytic anemia: Weakness, pale or yellowish skin, or dizziness.
Drug Interactions
Avoid concomitant use with serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), and opioids. Taking serotonergic drugs together with methylene blue increases the risk of serotonin syndrome.
Warning: Do not take this medication if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency, due to an increased risk of hemolytic anemia.
Administration & Dosing
Use this medication exactly as prescribed. Contact your healthcare provider for specific dosing instructions.
Pregnancy, Breastfeeding & Pediatrics
Methylene blue may have the potential to cause fetal harm. Consult your healthcare provider if you are pregnant to discuss the risks and benefits. It is unknown whether methylene blue is excreted in human breast milk; one manufacturer recommends discontinuing breastfeeding during treatment and for up to 8 days after administration due to an increased risk of adverse reactions. Methylene blue may be safe and effective in neonates, infants, children, and adolescents — consult your healthcare provider for more information.
⚠️ Disclaimer: This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.
References
- DailyMed. PROVAYBLUE (methylene blue) injection [Internet]. Bethesda (MD): U.S. National Library of Medicine; 2025 May 28 [cited 2026 Jun 22]. Available from: dailymed.nlm.nih.gov
- Drugs.com. Methylene blue: uses, dosage, side effects, warnings [Internet]. Drugsite Trust; 2025 May 5 [cited 2026 Jun 22]. Available from: drugs.com
- Tatarinova O, Lund K, Bain BJ. Beware of methylene blue in possible G6PD deficiency. Am J Hematol. 2024;99(10):2016-2017. doi:10.1002/ajh.27324.
Methylene Blue
Consult your prescriber.
Use the medication as prescribed by your doctor. The information provided is not intended to cover all possible uses. This information is generalized and not intended as specific medical advice. If you have questions about the use of your prescription, please contact your prescriber.
Troches and suppositories require refrigeration (ice packs) and will incur an extra charge of $19.95 per order.
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